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Short Version
Biological and medical application of atmospheric plasmas
Biologische und medizinische Anwendung von Atmosphärendruck-Plasmen
Michael Orrico - PlasmaSol, Stryker Instruments, North Brunswick, NJ, USA Yelena Naumova - PlasmaSol, Stryker Instruments, North Brunswick, NJ, USA Shu-Min Yin - PlasmaSol, Stryker Instruments, North Brunswick, NJ, USA Ed Houston - PlasmaSol, Stryker Instruments, North Brunswick, NJ, USAGMS Krankenhaushyg Interdiszip 2008;3(1):Doc09
© 2008 Orrico et al.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.en). You are free: to Share - to copy, distribute and transmit the work, provided the original author and source are credited. |
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Short version
Atmospheric, non-thermal plasma (NTP) technology offers great promise to address several infection control issues in health care and life sciences. NTP-based processes have the ability to inactivate harmful infectious microorganisms (pathogens) with minimal impact to surrounding material and tissue. In addition, NTP processes offer advantages over antibiotics and chemical disinfectants: lethality against broad spectrum of pathogens including antibiotic-resistant organisms and viruses, and absence of environmentally-harmful by-products.
Most current research focuses on ex vivo applications: sterilization of heat and moisture sensitive medical devices, bio-waste management and air purification. An example of this type of application is the PlasmaSol technology with generating of active sterilizing radical species of to disinfect airborne, waterborne and surface pathogens.
Longer term, clinicians conceive of minimally-invasive, NTP-based therapies to treat in vivo persistent infections. These infections drastically increase morbidity and mortality in the growing immuno-compromised patient population. Specific applications will be discussed including ventilator-associated pneumonia, prosthetic-related endocarditis and septic failure of orthopedic implants.
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Kurzfassung
Nicht-thermische Plasmaverfahren (NTP) eröffnen vielve
Die gegenwärtige Forschung konzentriert sich auf Ex-vivo-Anwendungen wie Sterilisation von temperatur- und feuchtigkeitsempfindlichen Medizinprodukten, Behandlung von Bioabfall und Luftreinigung. Ein Beispiel ist die PlasmaSol-Technik zur Erzeugung von sterilisierenden Radikalen zur Keimzahlverminderung in Raumluft, Wasser und auf Oberflächen.
Längerfristige klinische Erwartungen betreffen die minimal-invasive In-vivo-Behandlung persistierender Infektionen unter Anwendung nicht-thermischer Plasmen. Derartige Infektionen erhöhen die Morbidität und Mortalität vor allem immungeschwächter Patienten, deren Anzahl zun
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| GMS Krankenhaushygiene Interdisziplinär | ISSN 1863-5245 | DGKH |